NSI-189 Mechanism of Action: Theories About How It Works

The mechanism of action of NSI-189 phosphate remains a trade secret. It has been speculated that NSI-189 binds to the glucocorticoid receptor in the brain. Glucocorticoid receptor binding could be form of negative feedback that decreases circulating cortisol. Cortisol is a stress hormone implicated in depression and other stress-related neuropsychiatric disorders.