A recent study (ref) investigated the effects of lisdexfetamine (Vyvanse) on cardiovascular health. Researchers recruited healthy adults treated with lisdexamfetamine and monitored their blood pressure over a four week period.
Lisdexamfetamine did not significantly affect blood pressure compared with placebo. But lisdexamfetamine did increase pulse by 2.8, 4.2, 5.2 beats per minute for the 30mg, 40mg, and 70mg doses, respectively.
The authors concluded that the effects of lisdexamfetamine on heart rate and blood pressure were not concerning.
In comparison, Adderall is more likely to adversely affect cardiovascular health. Adderall (mixed amphetamine salts) increases blood pressure, heart rate and heart contractility. But the effect of Adderall on blood pressure is usually modest and not sustained.
If you’re concerned about your blood pressure, Adderall can be more problematic because it’s rapidly released. Vyvanse releases d-amphetamine more slowly which is less stressful for your cardiovascular system.