Disclaimer: we don’t condone the use of prescription psychostimulants for recreational purposes. However, we also acknowledge that it’s more productive to disseminate harm reduction strategies rather than withhold useful safety information about the recreational use of Adderall.

Comparing Vyvanse with the Adderall high – what’s the verdict?

Vyvanse has limited recreational potential compared with Adderall.

Adderall is more potent and more strongly elicits norepinephrine release (in addition to dopamine), which contributes to euphoria and high that some Adderall users may experience.

Drugs that reach the brain more quickly tend to be more addictive. The route of administration, e.g., oral vs insufflation vs intravenous, affects the addictive potential. This factor contributes to the draw of cigarette smoking. Nicotine and related alkaloids in tobacco smoke hit the brain within 30 seconds of inhalation. That’s fast!

In the general comparison of Adderall vs Vyvanse, we said that Adderall is instant release, whereas Vyvanse is delayed-release. This limits the recreational potential of Vyvanse because the active drug, dextroamphetamine, is released slowly.

Vyvanse and Insufflation

lisdexamfetamine insufflation Insufflating (snorting) Vyvanse will not have the intended effect. Vyvanse is dextroamphetamine attached to the amino acid lysine by a peptide bond. This bond is easily broken in the acidic environment in the stomach, which allows the dextroamphetamine to be liberated and enter the blood stream.

In your nostrils, however, the dextroamphetamine will remain attached to the lysine, and so very little active drug will reach the brain. Removing Vyvanse from the capsule and crushing it up has no effect.